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pentobarbital will lessen the extent or result of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital will lessen the extent or effect of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers is not really proposedContrain